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Stress And Diabetes: What To Know For Your Diabetes Management Stress is any undue strain caused by a difficult situation. It can be physical, such as an illness or injury, or it can be mental, which is generally the kind of stress we hear about. Stress changes your hormone levels, and as diabetes management relies on hormone regulation (particularly insulin), stress affects diabetes management. When the body is stressed, it enters a “fight or flight” state, where hormones are secreted that allow the body to access more energy from th...